Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

Supplementary Table S1 - Patient Characteristics Supplementary Fig. S1 - IR-induced morphology and inflammatory responses Supplementary Fig. S2 - Apoptosis following IR Supplementary Fig. S3 - Morphology, Aquaporin and ??H2AX in Acini following IR Supplementary Fig. S4 - IL-6 is crucial for persistence of DDR Supplementary Fig. S5 - IL-6 infusion induces IL-6 upregulation. Supplementary Fig. S6 - IL-6 and HIL-6 pretreatment reduces persistent DDR Supplementary Fig. S7 - IL-6 pretreatment accelerates DNA damage repair Supplementary Fig. S8 - IL-6 deficiency does not affect DDR Supplementary Fig. S9 - HIL-6 pretreatment does not affect distal tumor radiotherapy Supplementary Figure Legends Supplementary Materials and Methods