Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms

Baohui Xu,Gang Li,Yankui Li,Hongping Deng,Anna Cabot,Jia Guo,Makoto Samura,Xiaoya Zheng,Tiffany Chen,Sihai Zhao,Naoki Fujimura,Ronald L. Dalman

JVS-Vascular Science（2023）

引用 2|浏览15

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摘要

Metformin treatment suppresses existing experimental AAA progression in part via AMPK agonist activity, limiting interferon-γ-producing T cell differentiation while enhancing circulating and splenic inflammatory monocyte retention.

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关键词

Abdominal aortic aneurysm,5′ AMP-activated protein kinase,Cytokine,Inflammatory monocytes,Metformin

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