Supplementary Figures 1 - 11 from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

PDF file - 856K, Selection of highly invasive oral cancer cells (S1); Overexpressing miR-491-5p inhibited lung metastasis in SCID mice (S2); The GIT1 mRNA level is upregulated in highly invasive OSCC lines (S3); GIT1 was overexpressed in the highly invasive oral cancer lines (S4); Knockdown of GIT1 by siRNA-3 had no affect paxillin mRNA expression (S5); DN-FAK suppresses GIT1-induced cell migration and invasion in OSCC cells (S6); Effect of ERK1/2 on MMP2/9 mRNA expression in OSCC cells (S7); Overexpression of miR-491-5p did not decrease proliferation in OSCC cells before 72h time point (S8); Effect of the DN-MEK or PD98059 on GIT1 induced MMP2/9 mRNA expression in OSCC cells (S9); Depletion of FAK and GIT1 decreased the paxillin and FAK phosphorylation (S10); CGHNC9 cells were transfected with FAM-labeled miR-491-5p (S11).