Effect of febuxostat on the level of malondialdehyde-modified low-density lipoprotein, an oxidative stress marker: A subanalysis of the PRIZE study.

Hiroki Teragawa,Atsushi Tanaka,Yuichi Fujii,Hisako Yoshida,Tomohiro Ueda,Shuichi Nomura,Toshiaki Kadokami,Hisashi Koide,Makoto Saito,Hiroaki Sano,Yasuko K Bando,Toyoaki Murohara,Koichi Node

Clinical cardiology（2023）

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摘要

Our findings may indicate a possibility that febuxostat can lower the MDA-LDL/LDL-C ratio, a potential marker of atherosclerosis and oxidative stress, in asymptomatic hyperuricemic patients with carotid atherosclerosis. Further studies are required to validate our findings and elucidate the clinical antioxidant effect of febuxostat.

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关键词

antioxidative effect,febuxostat,malondialdehyde-modified low-density lipoprotein,oxidative stress marker

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