Prognostic value of circulating tumor DNA using target next-generation sequencing in extensive-stage small-cell lung cancer.

Jiexia Zhang,Ningning Zhou,Huojin Deng,Xin Chen,Qunqing Chen,Qiongyao Wang,Lei Sun,Yang Wen,Xiaolong Cao,Zhiqiang Luo,Jian Zhang,Weiliang Zhu,Linlang Guo

Lung cancer (Amsterdam, Netherlands)（2023）

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摘要

Our study revealed a dynamic somatic mutation profile through continuous ctDNA detection and confirmed that ctDNA levels can reflect tumor burden and predict PFS in patients with extensive stage-SCLC. Furthermore, we demonstrated that plasma ctDNA assays can provide real-time information on somatic mutations for potential targeted therapies for SCLC.

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关键词

RB1,SCLC,Somatic mutations,TP53,ctDNA

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