Supplementary Figures S1 through S7 from CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8<sup>+</sup> T Cells

(1) Figure S1. Expression of CD39 and CD73 on CD8+T cells from different cancer models and tumor-free mice. (2) Figure S2. Expression of CD39 and CD73 on tumor-infiltrating CD45+ cells. Frequency of CD39high CD8+ TILs in tumors with different immunogenicity. (3) Figure S3. Functionality of CD39high CD8+ TILs in tumors with different immunogenicity. Expression of iRs and TFs on CD8+ T cells. (4) Figure S4. Phenotype of exhausted CD8+ T cells after re-stimulation. Data related to co-culture experiments. (5) Figure S5. Identification of tumor-infiltrating CD39+CD4+ Tconv cells. Characterization of CD39+CD8+ T cells from breast cancer patients. (6) Figure S6. Phenotypic and functional study of CD39+CD8+ T cells from melanoma patients. (7) Figure S7. Functional study of CD39+CD8+ T cells induced in vitro. Localization of CD39+CD45+ cells in hypoxic foci.