Supplementary Figure S4 from Molecular Evolution Patterns in Metastatic Lymph Nodes Reflect the Differential Treatment Response of Advanced Primary Lung Cancer

Figure S4. The genomic and transcriptomic pattern of TH6 case. (A) The mutation heatmap. (B) The scatter plot shows the similarity of gene expression profiles between nodes (using 15,842 genes with at least > 5 reads) by measuring Pearson's correlation coefficient (r). (C) The density plot of cancer cell fraction (CCF) between the primary and the lymph node. (D) The gene expression pattern of genes belonging to SQCCs, PI(3)K/RTK/RAS signaling. Gene expression values in lymph nodes were mapped on the distribution of gene expression in TCGA SQCCs (n=495), represented by the boxplot. AKT2 and RASA1 show significant clinical outcome difference in the gene expression of TCGA SQCCs patients; *P < 0.05.