Vascular endothelial growth factor inhibitors promote antitumor responses via tumor microenvironment immunosuppression in advanced colorectal cancer.

Yuki Hamada,Kiyonori Tanoue,Yoshiaki Kita,Kan Tanabe,Kentaro Hokonohara,Masumi Wada,Yuto Hozaka,Hideyuki Oi,Chieri Nakayama,Michiyo Higashi,Takaaki Arigami,Shinichiro Mori,Takao Ohtsuka

Scandinavian journal of gastroenterology（2023）

引用 3|浏览9

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摘要

In advanced colorectal cancer, VEGF inhibitors may decrease the number of PD-1 cells and inhibit the infiltration of FOXP3 lymphocytes and CD163monocytes into the tumor environment.

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关键词

Colorectal cancer,M2-type tumor-associated macrophage,bevacizumab,programmed cell death 1,regulatory T cell,vascular endothelial growth factor

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