Impact of Duodenal Pathology on Oral Drug Bioavailability and Disease Outcomes in Pediatric Crohn's Disease.

Rebecca Casini,Carrie A Vyhlidal,Julia M Bracken,Ashley K Sherman,Atif Ahmed,Vivekanand Singh,Veronica Williams,Valentina Shakhnovich

Pharmaceuticals (Basel, Switzerland)（2023）

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摘要

For children with Crohn's disease, duodenal pathology, marked by villous blunting, increased the risk of sub-therapeutic 6-TGN levels, despite higher azathioprine dosing during the first year post-diagnosis. Lower hemoglobin and BMI z-scores at 9 months post-diagnosis suggest the impaired absorption/bioavailability of nutrients, as well as oral drugs, in children with duodenal disease.

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关键词

Crohn’s disease,IBD,absorption,azathioprine,drug disposition,inflammatory bowel disease,oral drugs,pediatrics,thiopurine metabolites

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