Antifungal Action of Herbal Plants' Glycolic Extracts against Candida Species.

spp. cause fungal infection that affects patients' oral health. This study aimed to evaluate the isolated and synergistic antifungal effect of L., L., L., and L. glycolic extracts against , , , and planktonic and biofilm forms. The plant extracts were chemically characterized and the main compounds were quantified by high-performance liquid chromatography (HPLC-DAD) analysis. The minimum inhibitory and minimum fungicidal concentrations of the extracts were determined, and antibiofilm activity was evaluated by MTT assay. Data were analyzed by one-way ANOVA and Tukey's tests, and by Kruskal-Wallis and Dunn's tests, considering a significance level of 5%. The main compounds identified in each of the extracts were: p-coumaric acid (2153.22 μg/100 mL) in the rosemary extract, gallotannins (4318.31 μg/100 mL) in the pomegranate extract, quercetin derivatives (3316.50 μg/100 mL) in the extract of white roses, and curcumin (135.09 μg/100 mL) in the turmeric extract. The combination of and glycolic extracts was effective against , and biofilms over different periods ( < 0.05). The combination of and glycolic extracts was effective against and biofilms after 30 min, and against after 24 h, with all combinations showing an average reduction of 50% in cell viability ( < 0.05). In conclusion, the combined plant extracts have antifungal and antibiofilm action against spp. in different concentrations and times of action.