Neuroinflammation in Parkinson's Disease: From Gene to Clinic: A Systematic Review

Carlos Castillo-Rangel,Gerardo Marin,Karla Aketzalli Hernandez-Contreras,Micheel Merari Vichi-Ramirez,Cristofer Zarate-Calderon,Osvaldo Torres-Pineda, Dylan L. Diaz-Chiguer, David de la Mora Gonzalez, Erick Gomez Apo, Javier Alejandro Teco-Cortes, Flor de Maria Santos-Paez, Maria de los Angeles Coello-Torres,Matias Baldoncini,Gervith Reyes Soto,Gonzalo Emiliano Aranda-Abreu,Luis I. Garcia

International journal of molecular sciences(2023)

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摘要
Parkinson's disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation-PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.
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关键词
Parkinson's disease,gene expression,molecular pathways,cellular alterations,neuroanatomical alterations,neurobehavioral,clinical manifestations
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