Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC).

Balaji Chandrasekaran,Subhasish Tapadar,Bocheng Wu,Uttara Saran,Ashish Tyagi,Alexis Johnston,David A Gaul,Adegboyega K Oyelere,Chendil Damodaran

Cancers（2023）

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摘要

These results demonstrate that SBI-46 is a potent agent that inhibits preclinical models of CRPC by downregulating the expressions of both AR and AR-SV. Furthermore, these results suggest that SBI-46 may be a potent compound for treating CRPC.

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关键词

AR-V7,androgen receptor,castrate resistant prostate cancer,small molecule,splice variant

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