A new series of IDO1 inhibitors derived from microbial metabolites

Phytochemistry Letters(2023)

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摘要
Indoleamine 2,3-dioxygenase 1 (IDO1) is a rate-limiting enzyme catalyzing the metabolism of tryptophan along the kynurenine pathway, which has an effect on tumor immune escape, depression, inflammation, and neurodegenerative disease. Thus, IDO1 has become a promising therapeutic target in disease treatment, and IDO1 inhibitors have attracted much attention. In this study, we discovered a series of IDO1 inhibitors through high-throughput screening. The compounds belonged to angucyclinones. Compound 1 exhibited potent IDO1 inhibition in both enzymatic and cellular assays with IC50 values of 0.230 µM and 2.100 µM, respectively. Enzyme kinetics experiments revealed that Compound 1 was a reversible and uncompetitive inhibitor of IDO1. Furthermore, Compound 1 significantly reduced plasma kynurenine levels in a mouse model. This study identified potential IDO1 inhibitors for the development of new therapies in the treatment of multiple diseases.
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关键词
IDO1 inhibitors,High throughput screening,Microbial metabolites,Disease treatment
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