Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma

The novel use of blood-based biospecimens from a retro-spective cohort of 50 patients with osteosarcoma was recently studied. The potential clinical utility of sorting cell-free DNA by fragment size was defined, with shorter tumor-specific DNA enrichment providing prognostic value and allowing for streamlined molecular profiling of circulating tumor material.