Electrochemical-induced cross-coupling for organic and bioorganic synthesis

After decades of electrochemical synthesis, the prospect of constructing organic molecules and their late-stage functionalization using renewable energy has provided exciting and valuable alternatives to conventional synthetic methods. Accordingly, the main target for this field is the development of simple, mild, and oxidant/reductant-free strategies if electrosynthesis is to be widely applied. Remarkably, the area of electrochemical dehydrogenative cross-coupling research has recently attracted considerable interest. Several approaches for building new molecules via C–C, C–N, C–O, C–S, and C–X bond formations have been achieved. This technique has great potential for use in the preparation of complicated molecules and biorthogonal chemistry. In describing the constraints that are imposed on the modification of biomolecules, this area provides direction for further developing electrosynthesis from organic cross-coupling reactions to the synthesis of biologically important molecules.