Rif1 Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells.

Cheng Liu, Peng Yu,Zongna Ren,Fang Yao,Li Wang,Guang Hu,Pishun Li,Quanyi Zhao

Stem cell reviews and reports（2023）

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摘要

Rif1 is a key factor in regulating the pluripotency, self-renewal, and lineage specification of mESCs. Our research provides new insights into the key roles of Rif1 in connecting epigenetic regulations and signaling pathways for cell fate determination and lineage specification of mESCs.

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关键词

ERK signaling pathway,Germ layer differentiation,Histone modifications,Mouse embryonic stem cells,Rif1

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