ADP receptor P2Y12 is the capstone of the cross-talk between Ca2+ mobilization pathways dependent on Ca2+ ATPases sarcoplasmic/endoplasmic reticulum type 3 and type 2b in platelets

Miao Feng,Béatrice Hechler,Frédéric Adam,Christian Gachet,Anita Eckly,Alexandre Kauskot,Cécile V. Denis,Marijke Bryckaert,Régis Bobe,Jean-Philippe Rosa

Research and Practice in Thrombosis and Haemostasis（2023）

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Abstract

•Nicotinic-acid-adenine-dinucleotide-phosphate mobilizes SERCA3-ATPase Ca2+ stores initiating early ADP secretion in activated platelets.•The roles of the P2Y1 and P2Y12 ADP receptors were studied.•SERCA3-dependent ADP early release activates P2Y12 (and not P2Y1) and SERCA2b-dependent release.•Full platelet secretion relies on coupling of SERCA3 and SERCA2b stores mobilization via P2Y12.

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Key words

ADP,blood platelets,NAADP,P2 purinergic receptor (P2Y12,P2Y1),SERCA3

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