Bioinspired molecular engineering of bivalent aptamers by ligand-induced self-dimerization
Chemical Communications(2023)
Abstract
A bioinspired “point-and-shoot” molecular strategy is described for engineering noncovalent aptamers via K+-induced reassembly of a split G-quadruplex sequence at the end of monomeric aptamers. This design compensates for insufficient...
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Key words
bivalent aptamers,bioinspired molecular engineering,ligand-induced,self-dimerization
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