A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish
Sensors and Actuators B: Chemical（2023）
Abstract
A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.
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Key words
Fluorescent probe,Imaging,Hypochlorite,Mitochondria targeting,Viscosity
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