Beta isphenol A and its analogs migrated from contact materials into food and beverages: An updated review in sample preparation approaches

Bisphenols are used as monomers in the production of plastic materials, and they are likely to be detected in food contact materials. Due to their migration from these plastic packaging materials into food and beverages, the organoleptic properties of the products are changing and plenty of harmful effects on human health are caused, especially if consumers are exposed to higher levels of bisphenols than those established by legislation. However, because of their trace-level presence, their determination into food and beverage matrices is rather difficult. For this reason, sensitive, simple, rapid, and green methods are required to extract and preconcentrate the analytes of interest. Effective and representative tests are required as well, to evaluate the migration of bisphenols from plastic materials under realistic usage conditions. This review provides a detailed background of bisphenol A chemistry and legislation. Furthermore, it refers to bisphenol A migration test procedures and the recent advances of the last decade in the extraction of bisphenols from various matrices by using different sample preparation techniques prior to their chromatographic determination.