Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage.

Alejandro Cueto-Sánchez,Hao Niu,Ismael Álvarez-Álvarez,Bárbara López-Longarela,Enrique Del Campo-Herrera,Aida Ortega-Alonso,Miren García-Cortés,José Pinazo-Bandera,Judith Sanabria-Cabrera,Juan José Díaz-Mochón,M Isabel Lucena,Raúl J Andrade,Camilla Stephens,Mercedes Robles-Díaz

British journal of clinical pharmacology（2023）

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摘要

ccK18 appears promising in distinguishing DILI from autoimmune hepatitis but less so from other forms of acute liver injury. Osteopontin demonstrates prognostic potential with higher levels detected in more severe cases regardless of aetiology.

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关键词

DILI,cytokeratin 18,hepatotoxicity,liver biomarkers,microRNA-122,osteopontin,α-glutathione-S-transferase

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