Spatio-temporal patterns of malaria in Nepal from 2005 to 2018: A country progressing towards malaria elimination

•Nepal is preparing for elimination by 2026.•Spatial variation in temporal trend method used to detect and generate unusually high or low temporal trend of malaria indicators.•Indigenous malaria increasing by 113.71% and imported malaria increasing by 156.22% in two different clusters.•All indicators have clusters of increasing malaria trend.•The decreasing clusters also have rate of decrease lower than outside the clusters.