Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF.
Frontiers in immunology（2023）
摘要
Our data demonstrate that synergistic action of cytostatic agents and innovative immunomodulators is required to overcome cancer therapy resistance.
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关键词
EGF,breast cancer,cisplatin,clearance,endocytosis,stabilin-1,tumor-associated macrophage (TAM)
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