The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients.
Frontiers in cellular and infection microbiology（2023）
Abstract
In particular, Golwatinib provides a candidate for treatment and prophylaxis in elderly patients with Omicjon, suggesting further evaluation of the anti-SARS-CoV-2 activity of these compounds in cell culture. Further studies are needed to determine the utility of this finding through prospective clinical trials and identify other meaningful drug combinations.
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Key words
COVID-19,Nsp1,Omicron infection,XBB sub-variant,elderly patients,translational inhibition
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