An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma.
Clinical chemistry and laboratory medicine（2023）
Abstract
The RMP showed high analytical performance for aldosterone quantification in human serum and plasma. The traceability to SI units was established by qNMR content determination of aldosterone, which was utilized for direct calibration of the RMP. Thus, this candidate RMP is suitable for routine assay standardization and evaluation of clinical samples.
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Key words
SI units,aldosterone,isotope dilution-liquid chromatography-tandem mass spectrometry,qNMR,reference measurement procedure,traceability
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