The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease.

Hillary H Hammond,Marisa K Ames,Oliver Domenig,Brian A Scansen,Nuen Tsang Yang,Machelle D Wilson, Erin Sunshine, Kaitlyn Brunk, Allison Masters

Journal of veterinary internal medicine（2023）

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摘要

Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.

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关键词

angiotensin converting enzyme 2,equilibrium dialysis,heart failure,neurohormones,protease inhibition,urine aldosterone to creatinine ratio

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