Adverse effect of assisted reproductive technology-related hyperoestrogensim on the secretion and absorption of uterine fluid in superovulating mice during the peri-implantation period.

Xinru Xia,Yuan Zhang,Meng Cao, Xiang Yu,Li Gao,Lianju Qin,Wei Wu,Yugui Cui,Jiayin Liu

Frontiers in endocrinology（2023）

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摘要

ART-induced hyperoestrogenism reduces CLDN3, AQP8 and SCNN1β expression through ERα, thereby destroying tight junctions and water and sodium channels in the endometrial cavity epithelium, which may cause abnormal implantation due to abnormal uterine fluid secretion and absorption.

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关键词

assisted reproductive technology,embryo implantation,hyperoestrogenism,superovulation,uterine fluid

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