Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents

Tetrahedron Letters(2023)

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摘要
γ-Lactones are used as building blocks in the synthesis of several naturally occurring products and biologically active compounds. In this work, a method of constructing a γ-lactone ring with an oxygen atom substituted at the γ position, with a short reaction time, mild reaction conditions, simple operation, and stereoselectivity, was developed. Using this reaction, the synthesis of the γ-lactone ring with various substituents (mainly halogenated alkoxy groups) at the γ position is possible.
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关键词
Hypervalent iodine (III) reagent,γ-Lactone,Acetal,Lactonization,Stereoselective
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