Hypervalent Iodine-Mediated Synthesis of Sulfinimidate Esters from Sulfenamides.
Organic letters(2023)
摘要
In this study, we present a novel and efficient approach for the oxidative esterification of sulfenamides using phenyliodonium diacetate, enabling the synthesis of sulfinimidate esters and sulfilimines under mild and metal-free conditions, with yields reaching up to 99%. The protocol is readily scalable and compatible with a diverse range of substrates and functional groups, and we demonstrate its potential for late-stage functionalization of pharmacologically relevant molecules. Furthermore, we propose a plausible reaction mechanism to account for the observed sequence of events.
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关键词
sulfinimidate esters,sulfenamides,synthesis,iodine-mediated
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