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Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro.

Jin Chen,Guoping Zhu,Wenbo Xiao,Xiaosong Huang,Kewu Wang,Yi Zong

Diabetes, metabolic syndrome and obesity : targets and therapy（2023）

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Abstract
Our findings revealed that G-Rg1 exhibits strong anti-apoptosis ability in pancreatic tissues of type 1 diabetic mice and HG-induced RIN-m5F cells, and the mechanisms involved in activating AMPK and inhibiting mTOR-mediated autophagy, indicating that G-Rg1 may have the therapeutic and preventive potential for treating pancreatic injury in diabetic patients.
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Key words
AMPK,apoptosis,autophagy,diabetes mellitus,ginsenoside Rg1
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