Thiol-ene-mediated degradable POSS-PEG/PEG hybrid hydrogels as potential cell scaffolds in tissue engineering

•A star-shaped cross-linker of allyl-terminated PEG-functionalized POSS (POSS-PEG-Allyl) was synthesized.•Three POSS-PEG/PEG hydrogels with different solid contents were designed and developed through thiol-ene click reaction.•The mechanical strength and the degradation date can be adjusted by the solid content of the hybrid hydrogels.•The hybrid hydrogel has excellent cell compatibility which porous internal structure, which provide conditions for cell growth and proliferation.