Serological response to a third dose of SARS-CoV-2 vaccine according to previous infection history

Kenji Ota, Satoshi Murakami,Kaori Ishihara,Daisuke Sasaki,Tetsuya Usui,Fujiko Mitsumoto-Kaseida,Kei Sakamoto,Kosuke Kosai,Hiroo Hasegawa,Takahiro Takazono,Akitsugu Furumoto,Norichika Asoh,Hiroyuki Yoshimine,Toyomitsu Sawai, Masanari Onizuka, Noriaki Makimoto,Koichi Izumikawa,Hiroshi Mukae,Shigeru Kohno,Katsunori Yanagihara

Vaccine: X（2023）

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摘要

The IgG antibody titer against SARS-CoV-2 receptor binding protein (RBD) after mRNA vaccine were compared between those with and without previous infection (PI) for up to 48 weeks. Though sustained higher IgG-RBD were observed in the PI group after two doses of vaccines, both groups benefited from the booster shots of the third vaccine. This data supports the necessity of the booster shots to those with PI.

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关键词

Serological response,SARS-CoV-2 vaccine,Previous infection history,Booster shot

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