GRK6 palmitoylation increasing its membrance translocation promotes LPS-induced inflammation by PI3K/ AKT pathway in kuppfer cells

Limei Tao,Yaxin Liu,Guoqiang Fan, Hai Zhang,Yibo Zong,Xiaojing Yang

International Immunopharmacology（2023）

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摘要

•GRK6 has a pro-inflammatory effect in LPS-induced Kupffer cells.•LPS induced increased palmitoylation of GRK6 and translocation to the cell membrane.•GRK6 acted on inflammation through PI3K/ AKT signaling pathway.

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关键词

GRK6,Palmitoylation,Kupffer cells,Inflammation

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