Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics.

Short designer self-assembling peptide (dSAP) biomaterials are a new addition to hemostat group. It may provide diverse and robust toolboxes for surgeon to integrate wound microenvironment with much safer and stronger hemostatic capacity than conventional materials and hemostatic agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, and internal medical bleeding (IMB), et al., with respect to the optimal hemostatic formulation, dSAP biomaterials are the ingenious nanofiber alternatives to make bioactive neural scaffold, nasal packing, large mucosal surface coverage in gastrointestinal surgery (esophagus, gastric lesion, duodenum, and lower digestive tract), epicardiac cell delivery carrier, transparent matrix barrier, et al. Herein, in multiple surgical specialties, dSAP biomaterials-based nano hemostats achieve safe, effective and immediate hemostasis, facile wound healing, and potentially reduce the risks in delayed bleeding, rebleeding, postoperative bleeding or related complications. The biosafety in vivo, bleeding indications, tissue-sealing quality, surgical feasibility, and local usability are addressed comprehensively and sequentially and pursued to develop useful surgical techniques with better hemostatic performance. This article provides the state of art and all-round advancements of nano hemostatic approaches in surgery. Relevant critical insights will inspire exciting investigations on peptide nanotechnology, next-generation biomaterials, and better promising prospects in clinics. This article is protected by copyright. All rights reserved.