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Human umbilical-cord-derived mesenchymal stem cells in combination with rapamycin reduce cartilage degradation via inhibition of the AKT/mTOR signaling pathway.

Yanan Bie,Qianqing Chen,Jiahuan Xu,Baofang Ou,Boyu Chen,Yajin Guan,Shuilin Xie

Immunopharmacology and immunotoxicology（2023）

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Abstract
Our study provides new evidence to support the use of hUMSCs in combination with rapamycin as a potential candidate for OA treatment.
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Key words
Human umbilical-cord-derived mesenchymal stem cells,combination therapy,mTOR signaling pathway,osteoarthritis,rapamycin
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