The ghrelin agonist, HM01 activates central vagal and enteric cholinergic neurons and reverses gastric inflammatory and ileus responses in rats.

Pu-Qing Yuan,S Vincent Wu,Lixin Wang,Yvette Taché

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society（2023）

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摘要

Peripheral HM0 activates central vagal and myenteric cholinergic pathways that may influence both central and peripheral targets to prevent AS-induced gastric inflammatory and ileus.

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关键词

abdominal surgery,dorsal motor nucleus of the vagus,gastric cytokines,gastric ileus,ghrelin receptor 1a,myenteric neurons

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