Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function.

Paul Renauer,Jonathan J Park,Meizhu Bai,Arianny Acosta,Won-Ho Lee,Guang Han Lin,Yueqi Zhang,Xiaoyun Dai,Guangchuan Wang,Youssef Errami,Terence Wu,Paul Clark,Lupeng Ye,Quanjun Yang,Sidi Chen

bioRxiv : the preprint server for biology（2023）

引用 38|浏览23

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摘要

The authors identify the adenosine deaminase gene (ADA) as a regulatory gene that reprograms T cell metabolism. ADA-overexpression (OE) in α-CD19 and α-HER2 CAR-T cells increases proliferation, cytotoxicity, memory, and decreases exhaustion, and ADA-OE α-HER2 CAR-T cells have enhanced clearance of HT29 human colorectal cancer tumors .

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