Candidate Angiogenesis-Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study.

A Erim Pamuk,M Emre Gedik,Nilda Sutay Suslu,Gurcan Gunaydin

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery（2023）

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摘要

High serum levels of sVEGFR-1 and osteopontin as well as low serum levels of VEGFR-2 proved to be poor prognostic in terms of survival in laryngeal carcinoma. VEGF, sVEGFR1, VEGFR2, IGFBP-3, and osteopontin levels were found to be significantly increased in larynx cancer patients compared to the normal population. Further studies on osteopontin and sVEGFR-1 are required in order to determine their associations with recurrence.

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关键词

IGFBP-3,VEGF,VEGFR-2,angiogenesis,biomarker,in silico,laryngeal cancer,osteopontin,prognosis,sVEGFR-1

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