Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.

Yajie Qian,Deyan Chen,Yanan Zhu,Jing Wu,Yong Wang,Weidong Yang

International endodontic journal（2023）

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摘要

Our data support that HK1-mediated glycolysis plays a crucial role in the development of AP via upregulating the NLRP3 signalling pathway. Moreover, targeting HK1 may contribute to prevent the progression of AP, which has a potential clinical translation.

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NLRP3 signalling pathway,apical periodontitis,glycolysis,hexokinase 1

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