Environmental exposures are important risk factors for advanced liver fibrosis in African American adults.

Ning Ma,Rowena Yip,Sara Lewis,Amreen Dinani,Christina Wyatt,Michael Crane,Artit Jirapatnakul,Li Li,Costica Aloman,Meena B Bansal,Douglas Dieterich,Brooke Wyatt,David Yankelevitz,Claudia Henschke,Andrea D Branch

JHEP reports : innovation in hepatology（2023）

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摘要

Because liver disease often produces few warning signs, simple and inexpensive screening tests that can be performed by non-specialists are needed to allow timely diagnosis and linkage to care. This study shows that non-Hispanic Black persons have a distinctive set of risk factors that need to be taken into account when designing liver disease screening programs. Exposure to exogenous toxins may be especially important risk factors for advanced liver fibrosis in non-Hispanic Black persons.

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关键词

ALD, alcohol-associated liver disease,ALT, alanine aminotransferase,APC, annual percent change,Aetiology,BMI, body mass index,CI, confidence interval,Environmental toxins,FIB-4, Fibrosis-4,HBV, hepatitis B virus,HCV, hepatitis C virus,HR, hazard ratio,KI, kidney insufficiency,LF, liver fibrosis,MA, Mexican American,NAFLD, non-alcoholic fatty liver disease,NEI, no exposure identified,NHANES, National Health and Nutrition Evaluation Survey,NHB, non-Hispanic Black,NHW, non-Hispanic White,Non-invasive scores,O, other race,PCB, polychlorinated biphenyl,Q1–Q4, quartiles 1–4,Racial disparities,Screening,ULN, upper limit of normal,USFLI, US Fatty Liver Index,VH, viral hepatitis,WC, waist circumference

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