Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice.

Alba Matas-Céspedes,Jean-Martin Lapointe,Matthew J Elder,Gareth J Browne,Simon J Dovedi,Lolke de Haan,Shaun Maguire,Richard Stebbings

Frontiers in immunology（2023）

引用 0|浏览4

暂无评分

摘要

Our findings demonstrate the potential of humanized mouse models for preclinical evaluation of different immunotherapies and combinations, using acceleration of GvHD development as a surrogate of aggravated antigenic T-cell response against host.

查看译文

关键词

GvHD,humanized mice,immune checkpoint inhibitors,immunotherapy,preclinical safety assessment

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要