Aberrant expression of COL4A1 in age-related cataract and its effect on cell proliferation, apoptosis and gene expression changes.

Dan Zhu,Peng Li,Li Wang,Yuan He, Hui-Zi Zhang

International journal of ophthalmology（2023）

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摘要

Silencing of induces S-phase arrest, also inhibits the proliferation and enhance HLE-B3 apoptosis and EMT, and down-regulates the expression of , , and . Thus, the expression alteration of may play a critical role in the pathogenesis of ARC.

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COL4A1,age-related cataracts,human lens epithelial cell

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