The Updated WHO Classification Better Predicts Survival in Patients with Endocervical Adenocarcinoma (KROG 20-07).

We demonstrated that HPVI ADC exhibited inferior DFS and OS and higher rates of local and distant recurrence compared to HPVA ADC. Gastric- and serous-type HPVI ADCs and ISM-type HPVA ADC showed worse OS than other types of HPVI and HPVA ADCs, respectively. Our observation of significant differences in prognoses according to the histological types needs to be validated in larger cohorts of endocervical ADC patients.