SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake.
Neuro-oncology(2023)
摘要
SREBP2 displays context-specific regulation of cholesterol biology based on its availability in the microenvironment with induction of cholesterol biosynthesis in the tumor core and uptake in the margin, informing a novel treatment strategy for GBM.
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关键词
SREBP2,cholesterol,cholesterol biosynthesis,glioblastoma,glioblastoma stem cell
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