Polystyrene nanoplastics lead to ferroptosis in the lungs

Yuhao Wu,Junke Wang,Tianxin Zhao,Mang Sun,Maozhu Xu,Siyi Che,Zhengxia Pan,Chun Wu,Lianju Shen

Journal of advanced research（2023）

引用 6|浏览1

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摘要

•The specific mechanisms of PS-NP-induced pulmonary injury are unclear.•A mouse model of lung injury is created based on the real-world NP exposure in human.•PS-NP exposure induces ferroptosis in lung tissues and bronchial epithelial cells.•HIF-1α inhibition rescues PS-NP-induced ferroptosis in bronchial epithelial cells.•PS-NP exposure induces ferroptosis via the HIF-1α/HO-1signaling pathway in lungs.

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关键词

Polystyrene nanoplastics,Ferroptosis,Lung injury,Bronchial epithelial cells

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