Coliphage cocktails for controlling antimicrobial-resistant Escherichia coli: emphasizing polyphage and multihost interactions at different levels of multiplicity of infection.

Manikantha Benala,Murugadas Vaiyapuri,Karthika Raveendran,Joshy Chalil George,Visnuvinayagam Sivam,Madhusudana Rao Badireddy

Journal of applied microbiology（2023）

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Abstract

Polyphage cocktails of 2, 4, 6, 8, and 10 coliphages applied at an MOI of 1000 effectively suppressed the growth of antimicrobial-resistant E. coli. The results indicated phage-phage synergy in the lytic activity of several coliphage combinations at higher MOIs of 1000 and 100 while phage-phage antagonism was evidenced at lower MOIs of 10 and 1.

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Key words

E. coli ,antimicrobial resistance,coliphages,phage cocktails,phage–host interactions,polyphage combinations

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