FOXP1 regulates oxidative stress, SIRT1 expression, and resistance to chemotherapies in acute myeloid leukemia cells

Francoise Levavasseur,Samia Oussous, Tuerdi Zubaidan, Olivier Kosmider,Frédéric Pendino,David Rombaut, Didier Bouscary, Michaela Fontenay,Evelyne Lauret,Isabelle Dusanter-Fourt

Blood Advances（2023）

Cited 2|Views11

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Abstract

•FOXP1 upregulates the cell stress sensor SIRT1 and supports AML cell resistance to therapeutic treatments.•FOXP1 limits superoxide anion levels and oxidative stress of myeloid leukemia cells.

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