Genetic variants in RORA are associated with asthma and allergy markers in an admixed population.

Louise Correia Lima,Gerson de Almeida Queiroz,Ryan Dos Santos Costa,Neuza Maria Alcantara-Neves,Cíntia Rodrigues Marques,Gustavo Nunes de Oliveira Costa,Mauricio Lima Barreto,Camila Alexandrina Viana Figueiredo,Valdirene Leão Carneiro

Cytokine（2019）

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摘要

•RORA SNVs are associated with atopic and non-atopic asthma in an admixed population.•Haplotypes in RORA gene are associated with atopic sensitization.•IL-13 production by dust mite stimulus is associated with RORA SNV.•The G allele of rs17191519 is associated with IL-5 production in atopic individuals.

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B. germanica,B. tropicalis,D. pteronyssinus,GWAS,ILC2,LD,Periplaneta americana,sIgE,SPT,SNV

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