Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1.

Huangming Zhuang,Xunshan Ren,Yuelong Zhang,Fuze Jiang,Panghu Zhou

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association（2023）

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Abstract

TMAO significantly up-regulated Piezo1 expression and sensitized chondrocytes to mechanical loading, which may be closely related to the pathogenesis of OA.

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Key words

Chondrocyte,Mechanical strain,Mechanotransduction,Osteoarthritis,Piezo1,Trimethylamine-N-Oxide

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