Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation.

Haijing Guan,Jingwen Sun,Xiuying Liang,Wenjuan Yao

Current vascular pharmacology（2023）

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摘要

The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.

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关键词

COX5A,Mitochondrial respiratory chain,VSMC phenotypic modulation,intimal hyperplasia,oxidative stress

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